It is not necessary to use multiple programs to clean up your system. Depending on the level of maintenance needed, it is usually best to just use one program that is specifically designed for system maintenance and optimization. If you want to do a more comprehensive clean up, then there are a variety of programs available that can help you with different tasks like removing files, defragmenting your hard drive, etc. However, it is usually best to stick with just one program rather than using multiple programs as there may be conflicts between them.